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Cirsium setidens is a wild perennial plant species found in Korea that may have anti-oxidative, anti-adipogenic, and hepatoprotective activities. However, details of the toxicology of C. setidens remain unknown. This study was performed to evaluate the toxicological effects of an acute administration and 4-week repeated dosing of a C. setidens extract in Sprague-Dawley rats to ensure the safe use of this extract. C. setidens (1250, 2500, and 5000 mg/kg body weight/day) did not induce significant toxicological changes in groups matched by gender with respect to mortality, clinical signs, body weight, urinalysis, ophthalmoscopy, necropsy findings, hematology, and histopathology. Therefore, this study demonstrates that acute administration and 4-week repeated dosing of C. setidens extract orally using this administration protocol is safe.
Cirsium setidens, a wild perennial herb, has been used in Korean medicine for treating hemostasis, hematemesis, hematuria and hypertension . Previous studies have demonstrated that C. setidens contains several bioactive ingredients with various medicinal activities, including cytotoxicity against human cancer cell lines [15,16]. Some studies have also reported that C. setidens shows hepatoprotective activity against CCl.
Cirsium setidens (Dunn) Nakai, commonly known as gondre, is a perennial herb that grows predominantly in South Korea. It contains several bioactive phytochemicals with antioxidant, antiâ€‘cancer, antiâ€‘tumor and antiâ€‘inflammatory properties. The present study aimed to investigate the effects of methanolic extracts of gondre on osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). As characterized by nuclear magnetic resonance spectroscopy and matrixâ€‘assisted laser deposition/ionization (timeâ€‘ofâ€‘flight) mass spectrometry, the methanol extract of gondre was found to be enriched with pectolinarin. After 48 h, enhanced viability of hPDLSCs was observed in the presence of gondre compared with under control conditions, suggesting the biocompatibility of gondre. Notably, biocompatibility was markedly affected by gondre concentration in cultured media. Relatively high cell viability was observed in medium containing 0.05% gondre. Furthermore, mineralization was significantly higher in hPDLSCs in the presence of gondre compared with that in control cells, indicating their mineralization potential. Increased expression of various transcription markers, such as collagen 1, runtâ€‘related transcription factor 2, bone sialoprotein and alkaline phosphatase, was also detected when hPDLSCs were stimulated with gondre compared with in the control groups, further confirming the superior osteogenic potential of gondre extract for tissue engineering applications, particularly in bone tissues.Cho BY, Park MR, Lee JH, Ra MJ, Han KC, Kang IJ and Lee OH: Standardized Cirsium setidens Nakai ethanolic extract suppresses adipogenesis and regulates lipid metabolisms in 3T3-L1 adipocytes and C57BL/6J mice fed high-fat diets. J Med Food. 20:763–776. 2017. View Article : Google Scholar.Hwayoung NOH, Heejin LEE, Eunhye KIM, Ling MU, Young Kyoung RHEE, Chang-Won CHO, Jayong CHUNG, Inhibitory Effect of a Cirsium setidens Extract on Hepatic Fat Accumulation in Mice Fed a High-Fat Diet via the Induction of Fatty Acid β-Oxidation, Bioscience, Biotechnology, and Biochemistry, Volume 77, Issue 7, 23 July 2013, Pages 1424–1429, https://doi.org/10.1271/bbb.130049 (Source: academic.oup.com)