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Download the free E-Book "A How-To Guide to Cryptolepis" by signing up atThe roots of cryptolepis, also known as nibima, kadze, gangamau, Ghanaian quinine and yellow-dye root (Cryptolepis sanguinolenta) have been used in Ghanaian traditional medicine for treatment of malaria for many generations. A Ghanaian drug company developed an herbal tea formulation trademarked as Phyto-Laria based on this plant, and the clinical evaluation of its potential as a herbal drug treatment for malaria was conducted, with the results published in this issue of the journal by Bugyei, et al (page 3). The active antiplasmodial components found in the root are known to be the indoquinoline alkaloids, which independently have been to have shown to have both in vitro and in vivo activity against Plasmodium falciparum, including chloroquine-resistant strains.
Ethnopharmacological Relevance. Cryptolepis sanguinolenta is a scrambling thin-stemmed shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria, diarrhea, and respiratory conditions. This review discusses the traditional importance as well as the phytochemical, ethnomedical, pharmacological, and toxicological importance of this plant. Materials and Methods. Excerpta Medica Database, Google Scholar, Springer, and PubMed Central were the electronic databases used to search for and filter primary studies on Cryptolepis sanguinolenta. Results.
The detailed review of various studies conducted on C. sanguinolenta and some of its constituents gives an important body of proof of its potential therapeutic benefits and also of its use as a source of lead compounds with therapeutic potentials. Conclusion. The review on C. sanguinolenta is important in identifying grey areas in the research on this medicinal plant and also provides comprehensive data thus far to continue research on this plant.Cryptolepis sanguinolenta belongs to kingdom Plantae, phylum Magnoliophyta, class Equisetopsida. It is in the subclass Magnoliidae and superorder Asteranae. The plant belongs to order Gentianales, family Apocynaceae, subfamily Periplocoideae. This plant belongs to the genus Cryptolepis and the species sanguinolenta [28, 29]. Table 2 contains the various local names by which the plant is referred to in different localities. (Source:www.hindawi.com)