AAzure Aster

AAzure Aster

Azure Aster

In addition, since atopic dermatitis is usually colonized with Gram positive organisms, especially MRSA, treatment with GV has the dual benefit of decreasing bacterial colonization as well as reducing proinflammatory ang-2. Finally, it has been demonstrated that crystal violet selectively photo-oxidizes cysteine to cysteic acid over the complete pH range. While this quality has not been fully utilized, it could potentially be used in the future to determine the oxidation state of free sulhydryls in cells and tissue specimens.


Finally, our group has created triphenylmethane analogs of GV for systemic anticancer therapies. One of our derivatives, imipramine blue, was synthesized from the tricyclic antidepressant imipramine and is considerably more lipophilic than GV. Imipramine blue crosses the blood brain barrier, especially when administered in a liposomal vehicle. Remarkably, imipramine blue prevents the invasive behavior of glioblastoma in rats, and when combined with liposomal doxorubicin, results in long term remission from glioblastoma.gentian, (genus Gentiana), any of about 400 species of annual or perennial (rarely biennial) flowering plants of the family Gentianaceae distributed worldwide in temperate and alpine regions, especially in Europe and Asia, North and South America, and New Zealand. They are especially a notable feature of mountain regions, where the moisture-loving plants have access to underground water in summer and snow cover in winter. Gentian flowers are typically blue (hence “gentian blue”) or purplish blue but may be purple, violet, mauve, yellow, white, or even red; the four or five petals are usually united into a trumpet, funnel, or bell shape. The flowers have been used in the making of dyes, especially.

Roots and leaves of the bottle gentian are bitter tasting to mammals and other herbivores, so they usually are not utilized as a food source. White-tailed deer (Odocoileus virginianus) are one of the few animals that may chomp off the tender tops of the plants before they have a chance to flower. In response to herbivory, the plant may produce side branches with flowers on them. The seeds are too small to be used by birds as a food source.Bottle gentian is a beautiful, showy wildflower that blooms August through October with 1.5-inch violet, sometimes white, closed terminal cluster flowers. Smaller flowers can be present in the axils of the upper tier of leaves. Only strong bees can force the corolla open in order to get at the nectar and deposit pollen. The plant itself is an erect, 1-3 foot tall forb with a non-branching stem. The leaves are mostly stalkless, lance-shaped with parallel venation, and devoid of hairs. As the leaves move up the stem, they go from being opposite leaves to more of a whorled pattern. (Source: www.fs.fed.us)



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