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Goats rue
Here's our first ever content marketer, a young goat in Sicily, Italy who writes some of the best content on the entire internet.When taken by mouth: There isn't enough reliable information to know if goat's rue is safe or what the side effects might be. No harmful effects have been reported in humans, but fatal poisoning has occurred in grazing animals that ate large quantities of goat's rue.The appropriate dose of goat's rue depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for goat's rue. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Goat's rue (Galega officinalis) leaves and flowering tops contain numerous guanidine derivatives, including galegine which may cause hypoglycemia. Goat's rue is widely used internationally as a galactogogue.[1-4] No scientifically valid clinical trials support this use, although some old, poorly controlled studies found an effect. Galactogogues should never replace evaluation and counseling on modifiable factors that affect milk production.[5,6] Although it has a long history of use as a galactogogue, very limited scientific data exist on the safety and efficacy of goat's rue in nursing mothers or infants. In general, goat's rue is well tolerated, but it might cause hypoglycemia, so caution should be used in women taking antidiabetic drugs. Diarrhea and hepatomegaly occurred in a woman taking fennel, fenugreek, and goat's rue as galactogogues.[7] A group of 5 nursing mothers were given no herb for 5 days, 15 mL of a 5% of goat's rue infusion orally 3 times daily for 10 days, followed by another 5-day control period from days 15 to 20.
Their diet and environment were kept constant during the study period. Milk volume was measured daily and milk fat percentage was measured on days 5, 10, 15 and 20. The goat's rue had no effect on milk volume or fat content.[9] Because of the lack of randomization, blinding and controls, and small number of participants, no valid conclusion can be made from this study on the galactogogue effects oGoat's rue extract (Galegran, Rieswerke, [Graz, Austria]) was given in an unspecified dose to increase the milk supply in an old, uncontrolled observational study of 336 women whose milk production was thought to be lower than normal. Increased milk output of 30 to 60% was observed.[10] Because of the lack of randomization, breastfeeding support, and placebo control no valid conclusion can be made from this study on the galactogogue effects of goat's rue. (Source:f goat's rue. (Source:www.ncbi.nlm.nih.gov)
Gonzalez-Andres, F., Redondo, P. A., Pescador, R., and Urbano, B. Management of Galega officinalis L. and preliminary results on its potential for milk production improvement in sheep. New Zealand Journal of Agricultural Research 2004;47:233-245. Keeler, R. F., Baker, D. C., and Evans, J. O. Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L. Vet.Hum.Toxicol. 1988;30(5):420-423. View abstract.PUFAHL, K. and SCHREIBER, K. [Isolation of a new guanidine derivative from goat's rue, Galega officinalis L.]. Experientia 7-15-1961;17:302-303. View abstract.
Herbal":http://www.botanical.com/botanical/mgmh/r/ruegoa21.html Mooney MH, Fogarty S, et al. Br J Pharmacol. 2008 Apr;153(8):1669-77. doi: 10.1038/bjp.2008.37. Epub 2008 Feb 25. Palit P, Furman BL, Gray AI. J Pharm Pharmacol. 1999 Nov;51(11):1313-9. Nice, Frank J. Infant, Child, & Adolescent Nutrition. Volume 3, no 3, June 2011. Pg 129-131. Glueck CJ, Salehi M, Sieve L, Wang P.. J Pediatr. 2006 May;148(5):628-632. Tabares FP, Bedoya Jaramillo JV, and Ruiz-Cortés ZT. (2014). Pharmacological Overview of Galactogogues. Vet Med Int. 2014; 2014: 602894. Castoldi F, Pivetti V, Moiraghi L, Marangione P, Lista G. [Silymarin/galega administration in term and preterm mothers to sustain breast feeding: an observational study] [Article in Italian]. Minerva Pediatr. 2014 Oct;66(5):375-80. (Source:www.gaiaherbs.com)"