Open field

Open field

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Field

Behavioral tests were performed in the following sequence: Elevated plus maze, open field, rota-rod, forced swim test, holeboard test. The apparatuses (Bilek+Schüll GMBH; Vienna, Austria) were custom made as well as the software (TIBE V.1.0; Vienna, Austria) for analysis. Hole visits in the holeboard were recorded manually from videos.

Read allA young girl grows up playing with the boys to become a trailblazer in tackle football and quarterback for the first U.S. Women's National Team (Team USA). Another, becomes the first woman in NFL history to coach in a Super Bowl. OPEN FIELD provides an inside look at women in tac... (Source:www.imdb.com)

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= 10.50, p < 0.0001], which has been used to normalize individual differences in baseline activity [31, 32]. This effect achieved study-wide significance. The activity suppression ratio of the 8–12-month-old group was significantly higher than that of other age groups (Fig. 7c; 8–12 mo > 6–7, 4–5, and 2–3 mo, p = 0.0005, p < 0.0001, and p < 0.0001, respectively). These results suggest that aging is associated with impaired contextual fear memory.

Our large-scale analysis using a number of behavioral data from mice subjected to a behavioral test battery demonstrated that almost all the behaviors examined, including locomotor activity, anxiety-like behavior, social behavior, startle response, depression-related behavior, spatial learning and memory, and associative fear memory, gradually change from young adulthood to middle age. In this study, we used the data of C57BL/6J mice with, which are the most widely used inbred strain for creating genetically engineered mice and studying mouse behavioral phenotypes. These findings will provide further opportunities to understand the neurobiological processes underlying brain function and behavior that are changeable with age from early to middle life. (Source: molecularbrain.biomedcentral.com)