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Lu Bu:

Lu Bu:

Lu Bu

Across the Pacific Ocean, in the closely guarded temple for the Qin Shihuang, emperor of China, a golden figure stands tall. His name is Lu Bu and his back is made of bronze. He’s not just a statue, though. He’s a figure that guards the tomb of Qin Shihuang.

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Dr. Lu’s translational research program has adopted combined human and mouse molecular genetics approaches to identify a number of developmental genes that are important in kidney and urinary tract development and pathogenesis of CAKUT. The first human molecular genetics approach is to study individuals with CAKUT and apparent genetic defects, with the aim of using gene mutations, genomic imbalances and chromosomal rearrangements as signposts to identify disease-causal genes (reverse genetics) (Ref 2). Thereafter, molecular identification and analysis of disease genes as well as mutation studies in affected individuals with a familial pattern of CAKUT will be carried out (forward genetics) (Ref 2, 4). The second approach is to study temporal and spatial expression patterns of disease genes in humans and mouse models. Concurrently, the phenotype of knockout and transgenic mouse models will be studied to more fully elucidate the roles of disease genes in kidney and urinary tract development and disease. Once these disease genes (e.g. ROBO2, SLIT2, ZEB2) are identified, a multidisciplinary research approach will be taken to gain further mechanistic insights (in vivo and in vitro) on the role of these genes in normal and abnormal developmental processes of the kidney and urinary tract, and on the pathogenesis of CAKUT and kidney injury after birth (Ref 5-8). This multidisciplinary approach includes using biomedical research techniques in molecular genetics, developmental biology, protein biochemistry, molecular biology, pathology, and pharmacology. The goal of this research program is to provide new knowledge of the biological mechanism that leads to CAKUT and kidney injury after birth, which has already led to the discovery of novel drug targets and therapeutics for patients with chronic kidney disease (Ref 7-9) (https://www.eurekalert.org/pub_releases/2016-11/bumc-rip_1111516.php & https://www.eurekalert.org/pub_releases/2020-05/buso-rsn050420.php).

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You always have the option to opt-in/opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience. For more information on our privacy policy, please read our privacy statement linked in the footer of this website (GER/EN). In the Panda Entertainment fighter/strategy game series Sango Fighter, Lü Bu is a rather unremarkable Dragon to Cao Cao in the first game (having more moves than everyone else helps though), but gets a Historical Badass Upgrade in the second. For starters, he has 3 bars(300HP) compared to everyone else's 2 in the strategy mode. For another, if you can't kill him in a single "round"(defined as every faction taking a turn), he completely heals up by the next, even if he was down to a single HP. Everyone else has to settle for 20/25/30 HP healed per turn. For gameplay balance, that's justifiable, since he's the only faction that has no backup generals, so if he loses, it's game over for his owner(CPU or player). He also has 3 different ways to use up his super bar(projectile/uppercut/grab), compared to most others' 1 or 2. Those with projectiles get upgraded projectiles, some have super grabs, others, like Xu Ju(the fat guy with the yellow do-rag) have ONLY the super grab(which makes him dangerous up close, as he won't accidentally use up his bar on anything else). (Source: tvtropes.org)

 

 

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