FutureStarr

Ksr

Ksr

Ksr

Ksr

Ksr.com is a tool that lets you know not just what your friends are buying and why, but also from where they are buying it, and in what quantities. And you don’t need to be a friend to use it. Simply type in a product and it’ll show you what your peers are purchasing. There’s also a free tool that shows you what your friends are tracking on their fitness apps, like Fitbit, and what they earn per minute.

Ksr

Kinase suppressor of Ras (KSR) is a recently identified component of Ras-dependent signaling pathways. In this report, we show that murine KSR1 (mKSR1) cooperates with activated Ras to promote Xenopus oocyte maturation and cellular transformation and provide evidence that this cooperation occurs by accelerating mitogen and extracellular regulated kinase (MEK) and mitogen-activated protein kinase (MAPK) activation. We also find that mKSR1 associates with Raf-1 at the plasma membrane in a Ras-dependent manner, indicating the presence of a membrane-bound kinase signaling complex. Although mKSR1 is related structurally to Raf-1, our findings reveal striking functional differences between these proteins. In marked contrast to the isolated amino- and carboxy-terminal domains of Raf-1, the KSR amino terminus also cooperates with Ras, whereas the carboxy-terminal kinase domain blocks Ras signaling as well as MEK and MAPK activation. The isolated KSR kinase domain suppressed Xenopus oocyte maturation, cellular transformation, and Drosophila eye development, suggesting that separation of the amino- and carboxy-terminal domains has uncoupled the normal regulation of KSR as a positive effector of Ras signaling. Together, our findings indicate that mKSR1 is an integral component of the MAPK module functioning via a novel mechanism to modulate signal propagation between Raf-1, MEK1, and MAPK.

Jack Pilgrim, Anthony White and Larry Vaught sit in for the KSR crew to recap Kentucky's big win over North Carolina and discuss what's next after news comes the Louisville game is off due to COVID-19 issues within the UofL program. (Source: www.iheart.com)

Use

What used to be the "MangalaWiki" is accessible here. For some time now the wiki had been closed to modifications, with this new version it is no longer the case. Learn more about how you can contribute here. You don't have to be tech-savvy to provide your input or suggestions, and if it still is too daunting there are always the comments in every page or the contact page.What used to be the "MangalaWiki" is accessible here. For some time now the wiki had been closed to modifications, with this new version it is no longer the case. Learn more about how you can contribute here. You don't have to be tech-savvy to provide your input or suggestions, and if it still is too daunting there are always the comments in every page or the contact page.

So, take a look around, and make use of the social media! You can see Stan's personal selection of his favourite talks/interviews, skim through the archival list of interviews, refresh your memory about Sax, find out the meaning of 'Haj', and much more... There is quite a bit of content on the Mars trilogy and The Years of Rice and Salt, with more content on the way -- the site is an ongoing work.This course focuses on the functions, control and integration of the cardiovascular and pulmonary systems. It is designed to increase the student's knowledge of regulation and integration of the cardiovascular and respiratory systems in health and disease. Responses and adaptations to acute and chronic exercise will be used as a foundation upon which the concepts of control and integration will be explored. Clinical applications (e.g., exercise, high altitude) and pathophysiology (e.g., Type 2 diabetes, heart disease) will be reviewed. Prerequisite: KIN 200. This course may not be taken for credit if credit has already been obtained for KIN 413. Note: Credit will be granted for only one of KSR 513, KIN 513 or PEDS 513.This seminar explores nature, sport, parks, and travel at the crossroads of environmental and cultural history. It concerns ideas about nature expressed through outdoor pursuits and leisure from the 19th to the 21st century. Modern influences framed and promoted many outdoor pursuits and environments as natural, yet they were also culturally defined. Focused on Canada with international tangents, it studies conservation, adventure, wilderness, recreation, tourism, play, health, and body culture in outdoor life. Seminars may include topics such as natural history and field science, park origins and advocacy, mountaineering and paddling, snow sports and winter pastimes, expeditions and tours, wildlife and guiding, urban design and parks, outdoor education, youth movements and camps, nature art and literature, heritage and festivals, and tourism traced in cultural landscapes. Teaching encourages students from various disciplines to engage with history. Collaborative seminars and field trips incubate individualized research and writing to understand past and present concerns of people, place, and politics related to leisure and sustainability. Note: Credit will be granted for only one of KSR 504, KRLS 504 or PERLS 504.

 

 

Related Articles